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MessagePosté le: Ven 20 Mai - 03:04 (2016)    Sujet du message: ????? BJ?????@$???? 1? 20121002 Target= Répondre en citant




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Liu....J,....Liu....Y,....Habeebu....SS,....Klaassen....CD....(1999)....Metallothionein-null....mice....are....highly....susceptible....to....the....hematotoxic....and....immunotoxic....effects....of....chronic....CdCl2....exposureTorlakovic..EE,..Bilalovic..N,..Golouh..R,..Zidar..A,..Angel..S..(2006)..Prognostic..significance..of..PU.1..in..follicular..lymphoma.Cell..cycle..and..cell..division....Is..the..Subject..Area.."Cell..cycle..and..cell..division"..applicable..to..this..article?..Yes..No..Thanks..for..your..feedback(2006)..Inverse..correlation..between..Flt3..and..PU.1..expression..in..acute..myeloblastic..leukemiasLoading...metrics...Open...Access...Peer-reviewed...Research...Article...A...PU.1...Suppressive...Target...Gene,...Metallothionein...1G,...Inhibits...Retinoic...Acid-Induced...NB4...Cell...Differentiation...Naomi...Hirako,...Affiliation:...Division...of...Molecular...Hematology,...Kitasato...University...Graduate...School...of...Medical...Sciences,...Minami-ku,...Sagamihara,...Japan...⨯...Hiroko...Nakano,...Affiliation:...Division...of...Hematology,...Kitasato...University...School...of...Allied...Health...Sciences,...Minami-ku,...Sagamihara,...Japan...⨯...Shinichiro...Takahashi...*...E-mail:...shinkitasato-u.ac.jp...Affiliations:...Division...of...Molecular...Hematology,...Kitasato...University...Graduate...School...of...Medical...Sciences,...Minami-ku,...Sagamihara,...Japan,...Division...of...Hematology,...Kitasato...University...School...of...Allied...Health...Sciences,...Minami-ku,...Sagamihara,...Japan...⨯...A...PU.1...Suppressive...Target...Gene,...Metallothionein...1G,...Inhibits...Retinoic...Acid-Induced...NB4...Cell...Differentiation...Naomi...Hirako,...Hiroko...Nakano,...Shinichiro...Takahashi...x...Published:...July...29,...2014...Article...Authors...Metrics...Comments...Related...Content...Reader...Comments...(0)...Media...Coverage...Figures...Figures...AbstractWe...recently...revealed...that...myeloid...master...regulator...SPI1/PU.1...directly...represses...metallothionein...(MT)...1G...through...its...epigenetic...activity...of...PU.1,...but...the...functions...of...MT1G...in...myeloid...differentiation...remain...unknowndoi:....10.1038/299797a0....View....Article....PubMed/NCBI....Google....Scholar....8OSM....induces....differentiation....in....myeloid....cells....and....is....mainly....produced....by....activated....T....lymphocytes,....monocytes,....and....macrophages....[27]The..p53..protein..levels..were..highest..in..MT..null..cells,..which..may..also..suggest..a..role..for..an..inhibitory..function..of..MT..toward..p53Cytokine....Growth....Factor....Rev....11:....177183MT1G..overexpression..disturbs..ATRA-induced..expression..changes..of..myeloid..differentiation..markers..After..establishing..NB4MTOE..cells,..we..examined..whether..the..overexpression..of..MT1G..could..alter..ATRA-induced..NB4..cell..differentiationCompared..with..other..tumors,..however,..studies..on..MT..in..hematological..malignancies..are..relatively..scarce.PU.1..is..a..hematopoietic..transcription..factor,..encoded..by..the..SPI1..gene,..expressed..in..granulocytic,..monocytic,..and..B-lymphoid..cells..[9]Quaife....CJ,....Findley....SD,....Erickson....JC,....Froelick....GJ,....Kelly....EJ,....et....alTsai...FY,...Orkin...SH...(1997)...Transcription...factor...GATA-2...is...required...for...proliferation/survival...of...early...hematopoietic...cells...and...mast...cell...formation,...but...not...for...erythroid...and...myeloid...terminal...differentiationdoi:..10.1038/ng1361..View..Article..PubMed/NCBI..Google..Scholar..12Cells....were....cultured....under....5%....CO2....at....37C....in....a....humidified....atmosphere.Microarray....and....mRNA....expression....analysesFor....RNA....preparation....for....real-time....PCR....analyses,....MT1G-overexpressing....(NB4MTOE)....cells....and....their....control....cells....were....seeded....at....a....density....of....1105....cells/ml....and....treated....with....1....M....all-trans....retinoic....acid....(ATRA)....or....an....equal....volume....of....its....solvent....(ethanol)The..data..presented..were..obtained..from..three..independent..PCR..amplifications,..and..the..reproducibility..was..confirmed..by..independent..real-time..PCR..amplifications..using..different..batches..of..cDNAWhen....compared....with....wild-type....mice,....the....macrophages....from....MT1/2....double-knockout....mice....showed....defects....in....their....phagocytic....and....antigen-presenting....activityMicroarray....and....mRNA....expression....analyses....For....RNA....preparation....for....real-time....PCR....analyses,....MT1G-overexpressing....(NB4MTOE)....cells....and....their....control....cells....were....seeded....at....a....density....of....1105....cells/ml....and....treated....with....1....M....all-trans....retinoic....acid....(ATRA)....or....an....equal....volume....of....its....solvent....(ethanol)Cell..Cycle..8:..365736626A)Considering..the..positive..role..of..MT..for..differentiation..in..the..megakaryocytic..lineage..[35]..and..the..negative..role..of..MT..for..erythroid..differentiation..[34],..the..roles..of..MT..toward..differentiation..may..differ..in..different..lineagesAlthough...some...differences...in...phenotypes...and...metabolic...responses...may...exist,...susceptibility...to...heavy...metal...toxicity,...responses...to...inflammation,...and...altered...zinc...homeostasis...are...common...features...of...the...phenotypes...of...these...double-knockout...miceTo...verify...equal...loading...of...proteins...in...each...lane,...anti-histone...H3...(for...nuclear...extracts)...and...anti-GAPDH...(for...total...cellular...extracts)...rabbit...polyclonal...antibodies...(Cell...Signaling...Technology)...were...also...employedThere....are....several....isoforms....of....MT1Since....G1....arrest....is....a....hallmark....of....ATRA-induced....NB4....cell....differentiation,....we....observed....a....decrease....in....G1....accumulation,....as....well....as....decreases....in....p21WAF1/CIP1....and....cyclin....D1....inductions,....by....ATRA....in....NB4MTOE....cellsdoi:...10.1016/j.leukres.2008.09.028...View...Article...PubMed/NCBI...Google...Scholar...17MT....was....expressed....in....leukemic....cells....from....68%....of....cases....with....newly....diagnosed....AMLWe..found..that..GATA..2..expression..was..reduced..in..ATRA-treated..control..cells,..but..this..reduction..was..tended..to..be..disturbed..in..NB4MTOE..cells..(FigBlack...bars:...NBT...strongly...positive...cells...(++);...gray...bars:...NBT...weakly...positive...cells...(+);...white...bars:...NBT...negative...(-)...cellsRosenbauer..F,..Wagner..K,..Kutok..JL,..Iwasaki..H,..Le..Beau..MM,..et..al3B,..C)J..Nutr..138:..2008S–2015S..[PMC..free..article]..[PubMed]22Central)GMT..+10GMT..+11GMT..+12GMT..+13..Play..Style..Social..Progression..Player..vs..Player..Roleplaying..Crafting..Leveling..Competitive..Loot..Rules..Sort..ByMost..ActiveMost..MembersMost..Characters..OathswornWorld..of..Warcraft..on..US..-..Wyrmrest..AccordActivity:..2..Members..-..0..Characters..-..Eastern..Timezone..-..EnglishTesting..FeaturesElder..Scrolls..Online..on..North..AmericaActivity:..2..Members..-..0..Characters..-..Eastern..Timezone..-..EnglishNightwolvesAge..of..Conan..on..CromActivity:..3..Members..-..0..Characters..-..Eastern..Timezone..-..EnglishDragonsworn..CouncilWorld..of..Warcraft..on..US..-..SentinelsActivity:..2..Members..-..122..Characters..-..Eastern..Events..-..Eastern..Timezone..-..EnglishThe..Westfold..MarshalsLord..of..the..Rings..Online..on..RiddermarkActivity:..2..Members..-..60..Characters..-..Eastern..Timezone..-..EnglishArmy..of..EldarLord..of..the..Rings..Online..on..[EN]..-..EvernightActivity:..2..Members..-..0..Characters..-..Eastern..Timezone..-..EnglishTeam..SlipstreamOverwatch..on..North..AmericaActivity:..3..Members..-..0..Characters..-..Eastern..Timezone..-..EnglishHellfireFinal..Fantasy..XIV:..A..Realm..Reborn..on..CactuarActivity:..2..Members..-..2..Characters..-..Eastern..Timezone..-..EnglishHellzinkoWorld..of..Warcraft..on..EU..-..English..-..Emerald..DreamActivity:..2..Members..-..1..Characters..-..0..Timezone..-..EnglishTAKENStar..Wars:..The..Old..Republic..on..The..Ebon..HawkNew..guild..looking..for..officers..and..membersDownload:...PPT...PowerPoint...slide...PNG...larger...image...()...TIFF...original...image...()...Figure...6(1995)...Neutrophils...and...monocytes...express...high...levels...of...PU.1...(Spi-1)...but...not...Spi-B(2012)..The..differentiating..and..apoptotic..effects..of..2-aza-5'-deoxycytidine..are..dependent..on..the..PU.1..expression..level..in..PU.1-transgenic..K562..cellsTwo...other...members,...MT3...and...MT4,...are...expressed...in...limited...types...of...tissues...[5],...[6]AbstractWe..recently..revealed..that..myeloid..master..regulator..SPI1/PU.1..directly..represses..metallothionein..(MT)..1G..through..its..epigenetic..activity..of..PU.1,..but..the..functions..of..MT1G..in..myeloid..differentiation..remain..unknown 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